| Alias | IL2 诱导型 T 细胞激酶, Human ITK Protein, GST Tag, ITK |
| Catalog Number | KMP3553 |
| Product Description | The Human ITK Protein(KMP3553) is produced in Insect Cells. The target gene encoding the human ITK (NP_005537.3) (Arg352-Leu620) is expressed with a GST tag at the N-terminus. The purified ITK is actived by LCK. |
| Molecular Name | ITK |
| Species | Human |
| Host | Insect Cells |
| Size | 50ug, 100ug, 200ug |
| Purity | >75% as determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | 50mM Tris, 150mM NaCl, 25% Glycerol, 0.5mM PMSF, 0.5mM TCEP, 0.1mM EDTA, 0.5mM GSH, pH7.5 |
| Background | IL-2-inducible T cell kinase is a member of the protein kinase superfamily, Tyr protein kinase family, and TEC subfamily. It contains 1 Btk-type zinc finger, 1 PH domain, 1 protein kinase domain, 1 SH2 domain, and 1 SH3 domain. As an intracellular kinase expressed in T-cells, IL-2-inducible T cell kinase contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. It regulates the development, function, and differentiation of conventional T-cells and nonconventional NKT-cells. IL-2-inducible T cell kinase also plays an essential role in the regulation of the adaptive immune response. Effects in IL-2-inducible T cell kinase are the cause of lymphoproliferative syndrome EBV-associated autosomal type 1 (LPSA1). LPSA1 is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Inadequate immune response to EBV can have a fatal outcome. Clinical features include splenomegaly, lymphadenopathy, anemia, thrombocytopenia, pancytopenia, recurrent infections. There is an increased risk of lymphoma. |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice. |
| Molecular Weight | 57.7 kDa |
400-621-6806
614353794
周一至周五 9:00-18:00
0
