Human CDK1 & CCNE1 Heterodimer Protein, His Tag, GST Tag_天津卡梅德科技发展有限公司

>>

>>

>>

>

Human CDK1 & CCNE1 Heterodimer Protein, His Tag, GST Tag

Human CDK1 & CCNE1 Heterodimer Protein, His Tag, GST Tag

产品编号

KMP3538

别名

CDK1和CCNE1的异二聚体蛋白, Human CDK1 & CCNE1 Heterodimer Protein, His Tag, GST Tag, CDK1 & CCNE1 Heterodimer

规格

50ug
100ug
200ug

DATASHEET MSDS

立即询价加入询价列表大包装定制

产品介绍

Alias	CDK1和CCNE1的异二聚体蛋白, Human CDK1 & CCNE1 Heterodimer Protein, His Tag, GST Tag, CDK1 & CCNE1 Heterodimer
Catalog Number	KMP3538
Product Description	The Human CDK1 & CCNE1 Heterodimer Protein(KMP3538) is produced in Insect Cells. The target gene encoding the human CDC2 (NP_001777.1) (Met1-Met297) is expressed with a GST tag at the N-terminus, constructed the plasmid 1; The target gene encoding the human CCNE1 (NP_001229.1) (Met1-Ala410) is expressed with a polyhistidine tag at the N-terminus, constructed the plasmid 2. The two plasmids are co-expressed and the heterotrimer is purified.
Molecular Name	CDK1 & CCNE1 Heterodimer
Species	Human
Host	Insect Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	20mM Tris, 500mM NaCl, 2mM GSH, 10% Glycerol, pH8.0
Background	CDK1 (Cyclin Dependent Kinase 1) is a Protein Coding gene. Diseases associated with CDK1 include Polyploidy and Retinoblastoma. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Loss of Nlp from mitotic centrosomes. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK2. Cyclin E, while currenly not as widely implicated as its cyclin D counterparts, has been implicated in various carcinomas, including breast, gastric, stomach and colorectal. High levels of cyclin E, either by gene amplification or overexpression, have been shown to lead to poorer prognosis in gastic carcinoma, and these measurements are correlated with later stage disease. In lung cancer, neoplastic cells with higher levels of the cyclin E/CDK2 complex are more radiosensitive than their more lowly expressed counterparts.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	109.7 kDa

推荐产品

400-621-6806
614353794
周一至周五 9:00-18:00
0