Human CES1 Protein, His Tag_天津卡梅德科技发展有限公司

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Human CES1 Protein, His Tag

Human CES1 Protein, His Tag

产品编号

KMP3520

别名

羧酸酯酶 1, Human CES1 Protein, His Tag, CES1

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	羧酸酯酶 1, Human CES1 Protein, His Tag, CES1
Catalog Number	KMP3520
Product Description	The Human CES1 Protein(KMP3520) is produced in HEK293 Cells. The target gene encoding the Human CES1 (NP_001020365) (Met1-Leu567) is expressed with a polyhistidine tag at the C-terminus.
Molecular Name	CES1
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	CES1 encodes carboxylesterase-1, an important drug-metabolizing enzyme with high expression in the liver. Variants generated by the exchange of segments with CES1P1 complicate the genotyping of CES1. CES1 is involved in the hydrolysis of ester group-containing xenobiotic and endobiotic compounds including several essential and commonly used drugs. The individual variation in the efficacy and tolerability of many drugs metabolized by CES1 is considerable. However, it has been problematic to express recombinant CES1 in bacterial expression systems due to low solubility, with the CES1 protein being mainly expressed in inclusion bodies, accompanied by insufficient purity issues. CES1 is capable of catalyzing the hydrolysis of a wide range of therapeutic agents, toxins, and endogenous compounds. Accumulating studies have demonstrated associations between the expression and activity of CES1 and the pharmacokinetics and/or pharmacodynamics of CES1 substrate medications.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	62.08 kDa

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