Human IRAK4 Protein, His Tag_天津卡梅德科技发展有限公司

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Human IRAK4 Protein, His Tag

Human IRAK4 Protein, His Tag

产品编号

KMP3508

别名

白介素 1 受体相关激酶 4, Human IRAK4 Protein, His Tag, IRAK4

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	白介素 1 受体相关激酶 4, Human IRAK4 Protein, His Tag, IRAK4
Catalog Number	KMP3508
Product Description	The Human IRAK4 Protein(KMP3508) is produced in Insect Cells. The target gene encoding the human IRAK4 (Q9NWZ3-2) (Met1-Ser336) is expressed with a polyhistidine tag at the C-terminus.
Molecular Name	IRAK4
Species	Human
Host	Insect Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	20mM PB, 300mM NaCl, 10% Glycerol, 0.5mM TCEP, pH7.0
Background	Interleukin-1 receptor-associated kinase 4, also known as Renal carcinoma antigen NY-REN-64, IRAK-4, and IRAK4, is a member of the protein kinase superfamily, TKL Ser/Thr protein kinase family, and Pelle subfamily. IRAK4 contains one death domain and one protein kinase domain. IRAK4 is required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. It also phosphorylates IRAK1. A member of the IL-1 receptor (IL-1R)-associated kinase (IRAK) family, IRAK4, has been shown to play an essential role in Toll-like receptor (TLR)-mediated signaling. IL-1-mediated IRAK4 kinase activity in T cells is essential for the induction of IL-23R expression, Th17 differentiation, and autoimmune disease. Pharmacological blocking of IRAK4 kinase activity will retain some levels of host defense while reducing the levels and duration of inflammatory responses, which should provide beneficial therapies for sepsis and chronic inflammatory diseases. Defects in IRAK4 are the cause of recurrent isolated invasive pneumococcal disease type 1 (IPD1) which is defined as two episodes of IPD occurring at least 1 month apart, whether caused by the same or different serotypes or strains. Recurrent IPD occurs in at least 2% of patients in most series, making IPD the most important known risk factor for subsequent IPD. Defects in IRAK4 are also the cause of IRAK4 deficiency which causes extracellular pyogenic bacterial and fungal infections in otherwise healthy children.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	40.01 kDa

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