Human PCSK9 Protein, mFc Tag_天津卡梅德科技发展有限公司

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Human PCSK9 Protein, mFc Tag

Human PCSK9 Protein, mFc Tag

产品编号

KMP3481

别名

前蛋白转化酶枯草杆菌蛋白酶, Human PCSK9 Protein, mFc Tag, PCSK9

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	前蛋白转化酶枯草杆菌蛋白酶, Human PCSK9 Protein, mFc Tag, PCSK9
Catalog Number	KMP3481
Product Description	The Human PCSK9 Protein(KMP3481) is produced in HEK293 Cells. The target gene encoding the human PCSK9 (NP_777596.2, with mutation Asp 374 Tyr) (Met1-Gln692) is expressed with the Fc region of mouse IgG1 at the C-terminus.
Molecular Name	PCSK9
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>85% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Proprotein convertase subtilisin/kexin type 9 (PCSK9), also known as NARC1 (neural apoptosis regulated convertase), which is a newly identified human secretory subtilase belonging to the proteinase K subfamily of the secretory subtilase family. PCSK9 protein is an enzyme which in humans is encoded by the PCSK9 gene with orthologs found across many species. It is expressed in neuroepithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells. PCSK9 protein is highly expressed in the liver and regulates low density lipoprotein receptor (LDLR) protein levels. Inhibition of PCSK9 protein function is currently being explored as a means of lowering cholesterol levels. Thereby, PCSK9 protein is regarded as a new strategy to treat hypercholesterolemia. PCSK9 protein contributes to cholesterol homeostasis and may have a role in the differentiation of cortical neurons.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	97.5 kDa

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