Human ART1 Protein, His Tag_天津卡梅德科技发展有限公司

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Human ART1 Protein, His Tag

Human ART1 Protein, His Tag

产品编号

KMP3458

别名

ADP核糖转移酶1, Human ART1 Protein, His Tag, ART1

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	ADP核糖转移酶1, Human ART1 Protein, His Tag, ART1
Catalog Number	KMP3458
Product Description	The Human ART1 Protein(KMP3458) is produced in HEK293 Cells. The target gene encoding the human ART1 (NP_004305.2) (Met1-Asn294) is expressed with a polyhistidine tag at the C-terminus.
Molecular Name	ART1
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Mono-ADP-ribosyltransferase (ART) 1 belongs to a family of mammalian ectoenzymes that catalyze the transfer of ADP-ribose from NAD+ to a target protein. ART1 is predominantly expressed in skeletal and cardiac muscle. It ADP-ribosylates alpha7-integrin which together with beta1-integrin forms a dimer and binds to laminin, a protein of the extracellular matrix involved in cell adhesion. This posttranslational modification leads to an increased laminin binding affinity. The differentiation-dependent upregulation of ART1 mRNA is induced by the binding of myogenin to an E box and of MEF-2 to an A/T-rich element in the proximal promoter region of the ART1 gene. Colorectal carcinoma is one of the most common cancers world-wide, with high morbidity and mortality rates. Arginine ADP-ribosyltransferase 1(ART1) is an important ecto-ADP-ribose transferase and has been proven to be intimately involved in a number of biological processes. The molecular mechanism for the function of ART1 in colorectal carcinoma and defines a potential therapeutic target for the enhanced treatment of this prominent world-wide disease
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	31.55 kDa

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