Human Claudin-9 Protein, His Tag, Avi Tag_天津卡梅德科技发展有限公司

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Human Claudin-9 Protein, His Tag, Avi Tag

Human Claudin-9 Protein, His Tag, Avi Tag

产品编号

KMP3452

别名

紧密蛋白 9, Human Claudin-9 Protein, His Tag, Avi Tag, Claudin-9

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	紧密蛋白 9, Human Claudin-9 Protein, His Tag, Avi Tag, Claudin-9
Catalog Number	KMP3452
Product Description	The Human Claudin-9 Protein(KMP3452) is produced in HEK293 Cells. The target gene encoding the human CLDN9 (O95484) (Met1-Thr184) is expressed, with a polyhistidine tag followed by an Avi tag at the C-terminus. The expressed protein is biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed.
Molecular Name	Claudin-9
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>80% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	10mM HEPES, 50mM NaCl, pH7.5
Background	Claudin-9 (CLDN9) belongs to the claudins family and is a transmembrane protein found in tight junctions with two extracellular loops and a cytoplasmic C tail. CLDN9 modulates the ion- and charge-specific permeability of the paracellular pathway in most epithelial tissues. It forms heterotypic interactions with other claudins to create cation-selective channels in the kidney and may contribute to the maintenance of alveolar barrier function in the lung. Deficiency is shown to be associated with autosomal recessive deafness, DFNB116. CLDN9 expression has been shown to be upregulated in certain types of cancer, such as endometrial cancer and hepatocellular carcinoma, and its knockdown has been found to reduce cell proliferation and migration in vitro.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	22.44 kDa

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