Human Claudin18 Protein_天津卡梅德科技发展有限公司

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Human Claudin18 Protein

Human Claudin18 Protein

产品编号

KMP3448

别名

紧密蛋白 18, Human Claudin18 Protein, Claudin18

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	紧密蛋白 18, Human Claudin18 Protein, Claudin18
Catalog Number	KMP3448
Product Description	The Human Claudin18 Protein(KMP3448) is produced in HEK293 Cells. The target gene encoding the human CLDN18 (P56856-1) (Met1-Val261) is expressed.
Molecular Name	Claudin18
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	50mM HEPES, 150mM NaCl, 10% Trehalose, pH7.2
Background	Claudins family member Claudin18 (CLDN18) is a four-pass transmembrane protein with two extracellular loops and cytoplasmic N- and C-tails found in tight junctions. CLDN18 modulates paracellular permeability, polarity, and signaling. CLDN18 deficiency has been associated with atrophic gastritis, spasmolytic polypeptide-expressing metaplasia (SPEM), and asthma. Lung-specific CLDN18.1 modulates alveolar epithelial type II (AT2) cell proliferation and organ size. Restoration of CLDN18.1 expression in human lung cancer cells has been shown to suppress proliferation, inhibiting the IGF-1R/AKT axes. Not expressed in other healthy tissues, gastric mucosa-specific isoform CLDN18.2 expression manifests in primary gastric cancers. CLDN18.2 at the surface of epithelial tumor cells is a target in antibody and CAR-therapies currently in development.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	27.86 kDa

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