Human HK2 Protein, His Tag_天津卡梅德科技发展有限公司

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Human HK2 Protein, His Tag

Human HK2 Protein, His Tag

产品编号

KMP3428

别名

己糖激酶 2, Human HK2 Protein, His Tag, HK2

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	己糖激酶 2, Human HK2 Protein, His Tag, HK2
Catalog Number	KMP3428
Product Description	The Human HK2 Protein(KMP3428) is produced in Insect Cells. The target gene encoding the Human HK2 (P52789) (Met1-Arg917) is expressed with a polyhistidine tag at the C-terminus.
Molecular Name	HK2
Species	Human
Host	Insect Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	20mM PB, 300mM NaCl, 10% Glycerol, pH7.0
Background	Hexokinase 2 (HK2), a rate-limiting enzyme in the first step of the glycolysis pathway, expresses at a high level in cancer cells compared with normal cells. HK2 provides a new target for cancer therapy due to its pivotal role in tumor tumourigenic and metastatic processes. The glycolytic enzyme hexokinase 2 (HK2) is crucial for the Warburg effect in human glioma, the most common malignant brain tumor. Although absent in most adult tissues, hexokinase 2 (HK2) is expressed in a majority of tumors and contributes to increased glucose consumption and to in vivo tumor 18F-FDG PET signaling. Hexokinase 2 (HK2) is a rate-determining enzyme in aerobic glycolysis, a process upregulated in tumor cells. HK2 expression is controlled by various transcription factors and epigenetic alterations and is heterogeneous in hepatocellular carcinomas (HCCs), though the cause of this heterogeneity is not known.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	103.84 kDa

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