Human GAD65 Protein, GST Tag_天津卡梅德科技发展有限公司

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Human GAD65 Protein, GST Tag

Human GAD65 Protein, GST Tag

产品编号

KMP3427

别名

谷氨酸脱羧酶, Human GAD65 Protein, GST Tag, GAD65

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	谷氨酸脱羧酶, Human GAD65 Protein, GST Tag, GAD65
Catalog Number	KMP3427
Product Description	The Human GAD65 Protein(KMP3427) is produced in Insect Cells. The target gene encoding the human GAD2 (NP_000809.1) (Met1-Leu585) is expressed with a GST tag at the N-terminus.
Molecular Name	GAD65
Species	Human
Host	Insect Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	50mM Tris, 150mM NaCl, 10% Glycerol, 1mM GSH, pH8.0
Background	Glutamate decarboxylase 2, also known as glutamate decarboxylase 65 kDa isoform, 65 kDa glutamic acid decarboxylase, GAD2 and GAD65, is a member of thegroup II decarboxylase family. GAD2 is identified as a major autoantigen in insulin-dependent diabetes. GAD2 is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. GAD2 may also play a role in the stiff man syndrome. GAD2 is implicated in the formation of the gamma-aminobutyric acid (GABA), a neurotransmitter involved in the regulation of food intake. GABA is synthesized in brain by two isoforms of glutamic acid decarboxylase (Gad), GAD1 and GAD2. GAD1 provides most of the GABA in brain, but GAD2 can be rapidly activated in times of high GABA demand. Mice lacking GAD2 are viable whereas deletion of GAD1 is lethal. Deletion of GAD2 increased ethanol palatability and intake and slightly reduced the severity of ethanol-induced withdrawal.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	92.6 kDa

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