Human SPI1 Protein, His Tag_天津卡梅德科技发展有限公司

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Human SPI1 Protein, His Tag

Human SPI1 Protein, His Tag

产品编号

KMP3410

别名

SPI1原癌基因蛋白 , Human SPI1 Protein, His Tag, SPI1

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	SPI1原癌基因蛋白 , Human SPI1 Protein, His Tag, SPI1
Catalog Number	KMP3410
Product Description	The Human SPI1 Protein(KMP3410) is produced in E. coli. The target gene encoding the Human SPI1 (P17947) (Met1-His270) is expressed, with a polyhistidine tag at the N-terminus.
Molecular Name	SPI1
Species	Human
Host	E. coli
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, 0.05% SKL
Background	SPI1 (also known as PU.1) is a dominant but transient regulator in early T-cell precursors and a potent transcriptional controller of developmentally important pro-T-cell genes. SPI1 is an essential transcription factor (TF) for the hematopoietic lineage, in which its expression is tightly controlled through a -17-kb upstream regulatory region and a promoter region. The E26 transformation-specific (ETS) family transcription factor PU.1/Spi1 acts as a master regulator of myeloid and lymphoid development. PU.1-deficient mice show a complete loss of microglia, indicating that PU.1 plays a pivotal role in micro-gliogenesis. The Spi1/PU.1 transcription factor is a key regulator of many steps of hematopoiesis, and limits self-renewal of hematopoietic stem cells. The deregulation of its expression or activity contributes to leukemia, in which Spi1 can be either an oncogene or a tumor suppressor.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	32.04 kDa

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