Human CD6 Protein, hFc Tag_天津卡梅德科技发展有限公司

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Human CD6 Protein, hFc Tag

Human CD6 Protein, hFc Tag

产品编号

KMP3408

别名

T细胞分化抗原CD6, Human CD6 Protein, hFc Tag, CD6

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	T细胞分化抗原CD6, Human CD6 Protein, hFc Tag, CD6
Catalog Number	KMP3408
Product Description	The Human CD6 Protein(KMP3408) is produced in HEK293 Cells. The target gene encoding the human CD6 (NP_006716.3) (Met1-Glu398) is expressed with the Fc region of human IgG1 at the C-terminus.
Molecular Name	CD6
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	T-cell differentiation antigen CD6, also known as TP12 and CD6, is a single-pass type I membrane protein which contains threeSRCR domains. CD6 / TP12 is a cell surface glycoprotein expressed primarily on T cells, it may function as a costimulatory molecule and may play a role in autoreactive immune responses. CD6 / TP12 is expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain. CD6 ligand termed CD166 (previously known as activated leukocyte cell adhesion molecule, ALCAM ) has been identified and shown to be expressed on activated T cells, B cells, thymic epithelium, keratinocytes, and in rheumatoid arthritis synovial tissue. CD6 / TP12 binds to activated leukocyte cell adhesion molecule ( CD166 ), and is considered as a costimulatory molecule involved in lymphocyte activation and thymocyte development. CD6 / TP12 partially associates with the TCR / CD3 complex and colocalizes with it at the center of the mature immunological synapse (IS) on T lymphocytes. During thymic development CD6-dependent signals may contribute both to thymocyte survival, and to the overall functional Avidity of selection in both man and mouse.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	67.3 kDa

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