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Human TSLP Protein, hFc Tag

Human TSLP Protein, hFc Tag

产品编号

KMP3358

别名

胸腺基质淋巴细胞生成素, Human TSLP Protein, hFc Tag, TSLP

规格
  • 50ug
  • 100ug
  • 200ug
产品介绍
Alias胸腺基质淋巴细胞生成素, Human TSLP Protein, hFc Tag, TSLP
Catalog NumberKMP3358
Product DescriptionThe Human TSLP Protein(KMP3358) is produced in HEK293 Cells. The target gene encoding the Human TSLP (NP_149024.1) (R127A, R130S, Met1-Gln159) is expressed with the fused Fc region of human IgG1 at the C-terminus.
Molecular NameTSLP
SpeciesHuman
HostHEK293 Cells
Size50ug, 100ug, 200ug
Purity>95% as determined by SDS-PAGE
PurificationAffinity purification
Endotoxin<1.0 EU/ug determined by the LAL method
FormulationPBS, pH7.4
BackgroundThymic stromal lymphopoietin (TSLP) is an interleukin 7 (IL-7)-like cytokine originally characterized by its ability to promote the activation of B cells and dendritic cells (DCs). Thymic stromal lymphopoietin (TSLP) is a cytokine expressed by epithelial cells, including keratinocytes, and is important in allergic inflammation. Subsequent studies have shown that TSLP promotes T helper type 2 (TH2) cell responses associated with immunity to some helminth parasites and the pathogenesis of many inflammatory diseases, including atopic dermatitis and asthma. TSLP can promote TH2 cytokine-associated inflammation by directly promoting the effector functions of CD4+ TH2 cells, basophils and other granulocyte populations while simultaneously limiting the expression of DC-derived proinflammatory cytokines and promoting regulatory T cell responses in peripheral tissues.
Storage ConditionAliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping ConditionIn general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight41.50 kDa

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