Human TSLP Protein, hFc Tag
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产品编号
KMP3358
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别名
胸腺基质淋巴细胞生成素, Human TSLP Protein, hFc Tag, TSLP
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规格
- 50ug
- 100ug
- 200ug
| Alias | 胸腺基质淋巴细胞生成素, Human TSLP Protein, hFc Tag, TSLP |
| Catalog Number | KMP3358 |
| Product Description | The Human TSLP Protein(KMP3358) is produced in HEK293 Cells. The target gene encoding the Human TSLP (NP_149024.1) (R127A, R130S, Met1-Gln159) is expressed with the fused Fc region of human IgG1 at the C-terminus. |
| Molecular Name | TSLP |
| Species | Human |
| Host | HEK293 Cells |
| Size | 50ug, 100ug, 200ug |
| Purity | >95% as determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | PBS, pH7.4 |
| Background | Thymic stromal lymphopoietin (TSLP) is an interleukin 7 (IL-7)-like cytokine originally characterized by its ability to promote the activation of B cells and dendritic cells (DCs). Thymic stromal lymphopoietin (TSLP) is a cytokine expressed by epithelial cells, including keratinocytes, and is important in allergic inflammation. Subsequent studies have shown that TSLP promotes T helper type 2 (TH2) cell responses associated with immunity to some helminth parasites and the pathogenesis of many inflammatory diseases, including atopic dermatitis and asthma. TSLP can promote TH2 cytokine-associated inflammation by directly promoting the effector functions of CD4+ TH2 cells, basophils and other granulocyte populations while simultaneously limiting the expression of DC-derived proinflammatory cytokines and promoting regulatory T cell responses in peripheral tissues. |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice. |
| Molecular Weight | 41.50 kDa |
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