Human Gastrokine 1 Protein, His Tag_天津卡梅德科技发展有限公司

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Human Gastrokine 1 Protein, His Tag

Human Gastrokine 1 Protein, His Tag

产品编号

KMP3353

别名

胃泌素 1, Human Gastrokine 1 Protein, His Tag, Gastrokine 1

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	胃泌素 1, Human Gastrokine 1 Protein, His Tag, Gastrokine 1
Catalog Number	KMP3353
Product Description	The Human Gastrokine 1 Protein(KMP3353) is produced in Insect Cells. The target gene encoding the human GKN1 (Q9NS71) (Asn35-Asn199) is expressed with a C-terminal polyhistidine tag.
Molecular Name	Gastrokine 1
Species	Human
Host	Insect Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	20mM Tris, 500mM NaCl, 10% Glycerol, pH8.0
Background	Gastrokine 1 (GKN1) belongs to the BRICHOS domain family and plays a major role in maintaining gastric mucosa integrity. GKN1 is highly expressed in gastric tissue and is secreted into the stomach but is not expressed in gastric cancer. GKN1-mediated inhibition of APP processing might represent a new approach for the prevention and therapy of Alzheimer's disease (AD). In the presence of GKN2, GKN1 loses its ability to decrease cell proliferation, induce apoptosis, and inhibit epigenetic alterations in gastric cancer cells, that GKN2 may contribute to the homeostasis of gastric epithelial cells by inhibiting GKN1 activity. The loss of GKN1 function contributes to malignant transformation and proliferation of gastric epithelial cells in gastric carcinogenesis.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	19.6 kDa

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