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Human KREMEN1 Protein, His Tag

Human KREMEN1 Protein, His Tag

产品编号

KMP3350

别名

Kringle 跨膜蛋白 1, Human KREMEN1 Protein, His Tag, KREMEN1

规格
  • 50ug
  • 100ug
  • 200ug
产品介绍
AliasKringle 跨膜蛋白 1, Human KREMEN1 Protein, His Tag, KREMEN1
Catalog NumberKMP3350
Product DescriptionThe Human KREMEN1 Protein(KMP3350) is produced in HEK293 Cells. The target gene encoding the human KREMEN1 (NP_114434.3) (Met1-Thr394) is expressed with a polyhistidine tag at the C-terminus.
Molecular NameKREMEN1
SpeciesHuman
HostHEK293 Cells
Size50ug, 100ug, 200ug
Purity>95% as determined by SDS-PAGE
PurificationAffinity purification
Endotoxin<1.0 EU/ug determined by the LAL method
FormulationPBS, pH7.4
BackgroundKREMEN1 (Kringle Containing Transmembrane Protein 1) is a Protein Coding gene. This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The cell surface molecule KREMEN1 is an entry receptor for coxsackievirus A1 (CV-A10). Whereas loss of KREMEN1 renders cells resistant to CV-A10 infection, KREMEN1 overexpression enhances CV-A10 binding to the cell surface and increases susceptibility to infection, indicating that KREMEN1 is a rate-limiting factor for CV-A10 infection. KREMEN1 is also essential for infection by a phylogenetic and pathogenic related group of Human type A Enteroviruses (EV-As). Diseases associated with KREMEN1 include Ectodermal Dysplasia 13, Hair/Tooth Type, and Hand, Foot, And Mouth Disease.
Storage ConditionAliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping ConditionIn general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight 42.6 kDa

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