Human TNFRSF11A Protein, mFc Tag_天津卡梅德科技发展有限公司

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Human TNFRSF11A Protein, mFc Tag

Human TNFRSF11A Protein, mFc Tag

产品编号

KMP3339

别名

肿瘤坏死因子受体超家族成员 11A, Human TNFRSF11A Protein, mFc Tag, TNFRSF11A

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	肿瘤坏死因子受体超家族成员 11A, Human TNFRSF11A Protein, mFc Tag, TNFRSF11A
Catalog Number	KMP3339
Product Description	The Human TNFRSF11A Protein(KMP3339) is produced in HEK293 Cells. The target gene encoding the human TNFRSF11A (NP_001257879.1) (Met1-Pro212) is expressed with the Fc region of mouse IgG2a at the C-terminus.
Molecular Name	TNFRSF11A
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	TNFRSF11A is a member of the TNF-receptor superfamily. In mouse, it is also known as CD265. TNFRSF11A contains 4 TNFR-Cys repeats and is widely expressed with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. It is an essential mediator for osteoclast and lymph node development. TNFRSF11A and its ligand are important regulators of the interaction between T cells and dendritic cells. It can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. Defects in TNFRSF11A can cause familial expansile osteolysis (FEO). FEO is a rare autosomal dominant bone disorder characterized by focal areas of increased bone remodeling. Defects in TNFRSF11A also can cause Paget disease of bone type 2 (PDB2). PDB2 is a bone-remodeling disorder with clinical similarities to FEO. Defects in TNFRSF11A are the cause of osteopetrosis autosomal recessive type 7 which characterized by abnormally dense bone, due to defective resorption of immature bone.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	46.5 kDa

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