Human KIRREL Protein, His Tag_天津卡梅德科技发展有限公司

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Human KIRREL Protein, His Tag

Human KIRREL Protein, His Tag

产品编号

KMP3279

别名

IRRE样蛋白的亲属 1, Human KIRREL Protein, His Tag, KIRREL

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	IRRE样蛋白的亲属 1, Human KIRREL Protein, His Tag, KIRREL
Catalog Number	KMP3279
Product Description	The Human KIRREL Protein(KMP3279) is produced in HEK293 Cells. The target gene encoding the human KIRREL (NP_060710.3) (Met1-Leu493) is expressed with a polyhistidine tag at the C-terminus.
Molecular Name	KIRREL
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	NEPH1 (KIRREL1) belongs to a family of three closely related transmembrane proteins of the Ig superfamily with a structure similar to that of nephrin. All three Neph proteins share a conserved podocin-binding motif; mutation of a centrally located tyrosine residue dramatically lowers the affinity of Neph1 for podocin. Neph1 triggers AP-1 activation similarly to nephrin but requires the presence of Tec family kinases for efficient transactivation. Neph1 consists of a signal peptide, five Ig-like C2-type domains with the middle domain overlapping with a PKD-like domain, an RGD sequence, a transmembrane domain, and a cytoplasmic tail, which is expressed in slit diaphragm domains of podocytes and vertebrate and invertebrate nervous systems. Neph1 is abundantly expressed in the kidney, specifically expressed in podocytes of kidney glomeruli, and plays a significant role in the normal development and function of the glomerular permeability. Neph1 interacts with nephrin in vitro and in vivo, and able to stimulate transcriptional activation in a model system, such as the activation of the transcription factor AP-1 via the stimulation of a MAPK module. Neph1 is crucial for the integrity of the slit diaphragm, as Neph1 gene knockout mice result in effacement of glomerular podocytes, heavy proteinuria, and early postnatal death.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	53.5 kDa

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