Human ATOX1 Protein, His Tag_天津卡梅德科技发展有限公司

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Human ATOX1 Protein, His Tag

Human ATOX1 Protein, His Tag

产品编号

KMP3249

别名

抗氧化因子 1 铜伴侣, Human ATOX1 Protein, His Tag, ATOX1

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	抗氧化因子 1 铜伴侣, Human ATOX1 Protein, His Tag, ATOX1
Catalog Number	KMP3249
Product Description	The Human ATOX1 Protein(KMP3249) is produced in E. coli. The target gene encoding the human ATOX1 (NP_004036.1) (Met1-Glu68) is expressed with a polyhistidine tag at the N-terminus.
Molecular Name	ATOX1
Species	Human
Host	E. coli
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	ATOX1 is a cytoplasmic copper chaperone that interacts with the copper-binding domain of the membrane copper transporters ATP7A and ATP7B. ATOX1 has also been suggested to have a potential anti-oxidant activity. As the trace element copper is essential, but extremely toxic in high concentrations, intracellular copper concentrations are tightly controlled. Once in the cell, copper is distributed by metallochaperones, including the small cytoplasmic protein ATOX1. ATOX1 plays an important role in the transfer of copper to the copper export P-type ATPases ATP7A and ATP7B to facilitate copper excretion. There is a novel function for Atox1 as a transcription factor (TF) regulating Ccnd1 was proposed. Antioxidant 1 (ATOX1) functions as an antioxidant against hydrogen peroxide and superoxide, and therefore may play a significant role in many human diseases, including diabetes mellitus (DM). The transduced Tat-ATOX1 protein protects pancreatic beta-cells by inhibiting STZ-induced cellular toxicity in vitro and in vivo. Thus Tat-ATOX1 protein has potential applications as a therapeutic agent for oxidative stress-induced diseases including DM.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	9.6 kDa

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