Human Amelotin Protein, mFc Tag_天津卡梅德科技发展有限公司

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Human Amelotin Protein, mFc Tag

Human Amelotin Protein, mFc Tag

产品编号

KMP3246

别名

釉蛋白, Human Amelotin Protein, mFc Tag, Amelotin

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	釉蛋白, Human Amelotin Protein, mFc Tag, Amelotin
Catalog Number	KMP3246
Product Description	The Human Amelotin Protein(KMP3246) is produced in HEK293 Cells. The target gene encoding the human AMTN (NP_997722.1) (Met1-Gln209) is expressed with the Fc region of mouse IgG1 at the C-terminus.
Molecular Name	Amelotin
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>75% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	50mM Tris, 100mM NaCl, 10% Glycerol, 0.5mM EDTA, pH8.5
Background	Amelotin (AMTN) is a tooth enamel protein which is expressed in maturation-stage ameloblasts and also in the internal basal lamina of junctional epithelium, a unique epithelial structure attached to the tooth surface which protects against the constant microbiological challenge to the periodontium. TNF-α stimulates AMTN gene transcription in human gingival epithelial cells via C/EBP1, C/EBP2, and YY1 elements in the human AMTN gene promoter.AMTN mRNA levels increased at 6 h and reached maximum at 24 h in GE1 cells. Luciferase activities of the mouse AMTN gene promoter constructs were induced by TGFβ1. AMTN mRNA levels were induced at the initiation of apoptosis by TGFβ1, which mediated through the Smad3 bindings to SBEs in the mouse AMTN gene promoter. Amelotin (Amtn) is a recently identified enamel protein secreted by ameloblasts at late stage of enamel development. Runt‑related transcription factor 2 (Runx2) in combination with the coactivator core‑binding factor β (Cbfβ) regulates the early stages of tooth development.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	46.2 kDa

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