Human RAB1B Protein, hFc Tag_天津卡梅德科技发展有限公司

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Human RAB1B Protein, hFc Tag

Human RAB1B Protein, hFc Tag

产品编号

KMP3231

别名

RAS 致癌基因家族成员, Human RAB1B Protein, hFc Tag, RAB1B

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	RAS 致癌基因家族成员, Human RAB1B Protein, hFc Tag, RAB1B
Catalog Number	KMP3231
Product Description	The Human RAB1B Protein(KMP3231) is produced in HEK293 Cells. The target gene encoding the human RAB1B (NP_112243.1) (Met1-Gly199) is expressed with the Fc region of human IgG1 at the N-terminus.
Molecular Name	RAB1B
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	RAB1B, a member of the RAS oncogene family, was significantly down-regulated in highly metastatic breast cancer cells. Moreover, down-regulation of RAB1B was also found to promote the proliferation and migration of TNBC cells in vitro and in vivo. Mechanistically, loss of RAB1B resulted in elevated expression of TGF-beta receptor 1 (TbetaR1) through decreased degradation of ubiquitin, increased levels of phosphorylated SMAD3 and TGF-beta-induced epithelial-mesenchymal transition (EMT). Furthermore, low RAB1B expression correlated with poor prognosis in breast cancer patients.RAB1B acts as a metastasis suppressor in TNBC by regulating the TGF-beta/SMAD signaling pathway and RAB1B may serve as a novel biomarker of prognosis and the response to anti-tumor therapeutics for patients with TNBC.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	50.4 kDa

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