Human ARF1 Protein, His Tag_天津卡梅德科技发展有限公司

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Human ARF1 Protein, His Tag

Human ARF1 Protein, His Tag

产品编号

KMP3172

别名

ADP-核糖基化因子 1, Human ARF1 Protein, His Tag, ARF1

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	ADP-核糖基化因子 1, Human ARF1 Protein, His Tag, ARF1
Catalog Number	KMP3172
Product Description	The Human ARF1 Protein(KMP3172) is produced in E. coli. The target gene encoding the human ARF1 (P84077) (Met1-Lys181) is expressed with a polyhistidine tag at the N-terminus.
Molecular Name	ARF1
Species	Human
Host	E. coli
Size	50ug, 100ug, 200ug
Purity	>85% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Invasion of tumor cells is a key step in metastasis that depends largely on the ability of these cells to degrade the extracellular matrix. The ARF1+ARF4 and ARF1+ARF3 pairs are both required for integrity of recycling endosomes but are involved in distinct transport pathways: the former pair regulates retrograde transport from endosomes to the TGN, whereas the latter is required for the transferrin recycling pathway from endosomes to the plasma membrane. The ADP-ribosylation factors (ARFs) 1 and 6 are small GTP-binding proteins, highly expressed and activated in several breast cancer cell lines and are associated with enhanced migration and invasiveness. ARF1 is a key role in invasion of breast cancer cells and suggest that targeting the ARF/Rho/MLC signaling axis might be a promising strategy to inhibit invasiveness and metastasis. ARF1 regulates cell migration and provide this GTPase as a target for the development of new therapeutics in triple negative breast cancer. ADP-ribosylation factor 1 (ARF1) is a crucial regulator in vesicle-mediated membrane trafficking and involved in the activation of signaling molecules. The aberrant MAPK signaling in prostate cancer is, at least in part, under the control of ARF1 and that, similar to Ras, ARF1 is a critical regulator in prostate cancer progression. ARF1 may represent a key molecular target for prostate cancer therapeutics and diagnosis.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	22.5 kDa

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