Human EPHX2 Protein, His Tag_天津卡梅德科技发展有限公司

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Human EPHX2 Protein, His Tag

Human EPHX2 Protein, His Tag

产品编号

KMP3168

别名

环氧化物水解酶 2, Human EPHX2 Protein, His Tag, EPHX2

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	环氧化物水解酶 2, Human EPHX2 Protein, His Tag, EPHX2
Catalog Number	KMP3168
Product Description	The Human EPHX2 Protein(KMP3168) is produced in Insect Cells. The target gene encoding the human EPHX2 (NP_001970.2) (Met1-Met555) is expressed with a polyhistidine tag at the N-terminus.
Molecular Name	EPHX2
Species	Human
Host	Insect Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	20mM Tris, 500mM NaCl, 10% Glycerol, pH7.4
Background	Genetic variation in EPHX2 was significantly associated with risk of incident CHD in Caucasians, implicating EPHX2 as a potential cardiovascular disease-susceptibility gene. Single nucleotide polymorphisms (SNPs) in the human EPHX2 gene had been implicated in susceptibility to cardiovascular disease, including stroke. The human EPHX2 mutations may in part explain the genetic variability in sensitivity to ischemic brain injury and stroke outcome. Epoxide hydrolase is involved in metabolism of vasoactive and anti-inflammatory epoxyeicosatrienoic acids to their corresponding diols. Consequently, epoxide hydrolase 2 (EPHX2) is a candidate cardiovascular disease (CVD) gene. Genetic variation in EPHX2 is associated with forearm vasodilator responses in a bradykinin receptor- and endothelium-independent manner, suggesting an important role for soluble epoxide hydrolase in the regulation of vascular function in humans. EPHX2 variants may mediate EETs levels, and low levels of EETs may be a predictor for END in acute MIS.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	65 kDa

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