Human NOTCH2NL Protein, mFc Tag_天津卡梅德科技发展有限公司

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Human NOTCH2NL Protein, mFc Tag

Human NOTCH2NL Protein, mFc Tag

产品编号

KMP3160

别名

Notch2氨基端样蛋白, Human NOTCH2NL Protein, mFc Tag, NOTCH2NL

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	Notch2氨基端样蛋白, Human NOTCH2NL Protein, mFc Tag, NOTCH2NL
Catalog Number	KMP3160
Product Description	The Human NOTCH2NL Protein(KMP3160) is produced in HEK293 Cells. The target gene encoding the human NOTCH2NL (XP_006711766.1) (Met1-Asn236) is expressed with the Fc region of mouse IgG1 at the N-terminus.
Molecular Name	NOTCH2NL
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	NOTCH2NLA (Notch 2 N-Terminal Like A) is a Protein Coding gene. NOTCH2NL, human-specific paralogs of the NOTCH2 receptor, stood out for their ability to promote cortical progenitor maintenance. It belongs to the NOTCH family. NOTCH2NL promote the clonal expansion of human cortical progenitors, ultimately leading to higher neuronal output. At the molecular level, NOTCH2NL function by activating the Notch pathway through inhibition of cis Delta/Notch interactions. NOTCH2NL ectopic expression delays differentiation of neuronal progenitors, while deletion accelerates differentiation into cortical neurons. The emergence of human-specific NOTCH2NL genes may have contributed to the rapid evolution of the larger human neocortex, accompanied by loss of genomic stability at the 1q21.1 locus and resulting recurrent neurodevelopmental disorders.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	52.5 kDa

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