Human NRBF2 Protein, His Tag, GST Tag_天津卡梅德科技发展有限公司

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Human NRBF2 Protein, His Tag, GST Tag

Human NRBF2 Protein, His Tag, GST Tag

产品编号

KMP3159

别名

核受体结合因子 2, Human NRBF2 Protein, His Tag, GST Tag, NRBF2

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	核受体结合因子 2, Human NRBF2 Protein, His Tag, GST Tag, NRBF2
Catalog Number	KMP3159
Product Description	The Human NRBF2 Protein(KMP3159) is produced in Insect Cells. The target gene encoding the human NRBF2 (Q96F24-1) (Met1-Asn287) is expressed with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
Molecular Name	NRBF2
Species	Human
Host	Insect Cells
Size	50ug, 100ug, 200ug
Purity	>85% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	20mM Tris, 500mM NaCl, 10% Glycerol, pH7.4
Background	NRBF2 (Nuclear Receptor Binding Factor 2) is a Protein Coding gene. The encoded protein may modulate transcriptional activation by target nuclear receptors. It is widely expressed in the appendix, placenta, and other tissues. NRBF2/Atg38 has been identified as the fifth subunit of the macroautophagy/autophagy class III phosphatidylinositol 3-kinase (PtdIns3K) complex, along with ATG14/Barkor, BECN1/Vps30, PIK3R4/p150/Vps15, and PIK3C3/Vps34. NRBF2 is a critical molecular switch of PtdIns3K and autophagy activation, and its on/off state is precisely controlled by MTORC1 through phosphorylation. NRBF2, a key component, and regulator of the PtdIns3K has been involved in APP-CTFs homeostasis in Alzheimer's disease (AD) cell models. NRBF2 plays an important role in regulating the degradation of APP-CTFs through modulating autophagy.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	60.2 kDa

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