Human MSH2 Protein, His Tag, GST Tag_天津卡梅德科技发展有限公司

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Human MSH2 Protein, His Tag, GST Tag

Human MSH2 Protein, His Tag, GST Tag

产品编号

KMP3146

别名

DNA错配修复蛋白MSH2, Human MSH2 Protein, His Tag, GST Tag, MSH2

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	DNA错配修复蛋白MSH2, Human MSH2 Protein, His Tag, GST Tag, MSH2
Catalog Number	KMP3146
Product Description	The Human MSH2 Protein(KMP3146) is produced in Insect Cells. The target gene encoding the human MSH2 (NP_000242.1) (Met1-Thr934) is expressed with a C-terminal polyhistidine-tagged GST tag at the N-terminus (His-GST).
Molecular Name	MSH2
Species	Human
Host	Insect Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	20mM Tris, 500mM NaCl, 10% Glycerol, 20mM GSH, pH7.4
Background	MSH2 is a key DNA mismatch repair protein, which plays an important role in genomic stability. In addition to its DNA repair function, MSH2 serves as a sensor for DNA base analogs-provoked DNA replication errors and binds to various DNA damage-induced adducts to trigger cell cycle arrest or apoptosis. Loss or depletion of MSH2 from cells renders resistance to certain DNA-damaging agents. Therefore, the level of MSH2 determines the DNA damage response.MSH2 is a central component of the mismatch repair pathway that targets mismatches arising during DNA replication, homologous recombination (HR), and in response to genotoxic stresses.MSH2 rearrangements are involved in approximately 10% of hereditary non-polyposis colorectal cancer (HNPCC) families, and in most of the rearrangements, exon 1 is deleted. Loss of human MSH2 (hMSH2) protein might be involved in the multistep pathogenesis of hematological malignancies associated with genetic instability.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	132.6 kDa

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