Human IL23 Receptor Protein, His Tag_天津卡梅德科技发展有限公司

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Human IL23 Receptor Protein, His Tag

Human IL23 Receptor Protein, His Tag

产品编号

KMP3115

别名

白细胞介素 23 受体, Human IL23 Receptor Protein, His Tag, IL23 Receptor

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	白细胞介素 23 受体, Human IL23 Receptor Protein, His Tag, IL23 Receptor
Catalog Number	KMP3115
Product Description	The Human IL23 Receptor Protein(KMP3115) is produced in HEK293 Cells. The target gene encoding the human IL23R (AAM44229.1) (Met1-Asp353) is expressed with a polyhistidine tag at the C-terminus.
Molecular Name	IL23 Receptor
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	IL23R, also known as the IL23 receptor, belongs to the type I cytokine receptor family, Type 2 subfamily. It contains 2 fibronectin type-III domains and is expressed by monocytes, Th1, Th0, NK, and dendritic cells. Isoform 1 is specifically expressed in NK cells. IL23R associates with IL12RB1 to form the interleukin-23 receptor. It binds IL23 and mediates T-cells, NK cells, and possibly certain macrophage/myeloid cell stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis. Genetic variations in IL23R are associated with inflammatory bowel disease type 17 (IBD17). IBD17 is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. Genetic variations in IL23R also can cause susceptibility to psoriasis type 7.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	39.3 kDa

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