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Human SPINK2 Protein, hFc Tag

Human SPINK2 Protein, hFc Tag

产品编号

KMP3092

别名

丝氨酸肽酶抑制因子 Kazal 2 型 , Human SPINK2 Protein, hFc Tag, SPINK2

规格
  • 50ug
  • 100ug
  • 200ug
产品介绍
Alias丝氨酸肽酶抑制因子 Kazal 2 型 , Human SPINK2 Protein, hFc Tag, SPINK2
Catalog NumberKMP3092
Product DescriptionThe Human SPINK2 Protein(KMP3092) is produced in HEK293 Cells. The target gene encoding the human SPINK2 (NP_066937.1) (Met1-Cys84) is expressed with the Fc region of human IgG1 at the C-terminus.
Molecular NameSPINK2
SpeciesHuman
HostHEK293 Cells
Size50ug, 100ug, 200ug
Purity>90% as determined by SDS-PAGE
PurificationAffinity purification
Endotoxin<1.0 EU/ug determined by the LAL method
FormulationPBS, pH7.4
BackgroundHuman serine proteinase inhibitor Kazal-type 2 (SPINK2) functions as a trypsin/acrosin inhibitor and is synthesized mainly in the testis and seminal vesicle where its activity is engaged in fertility. The SPINK2 protein contains a typical Kazal domain composed by six cysteine residues forming three disulfide bridges. The expression of SPINK2 is closely related to cancer such as lymphomas, in that a high transcript level of SPINK2 in patients with primary cutaneous follicle center cell lymphomas have better prognosis with lower mortality. SPINK2 is necessary to neutralize proteases during their cellular transit toward the acrosome and that its deficiency induces a pathological continuum ranging from oligoasthenoteratozoospermia in heterozygotes to azoospermia in homozygotes.
Storage ConditionAliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping ConditionIn general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight33.6 kDa

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