Human TMP21 Protein, mFc Tag_天津卡梅德科技发展有限公司

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Human TMP21 Protein, mFc Tag

Human TMP21 Protein, mFc Tag

产品编号

KMP3068

别名

跨膜 p24 运输蛋白 10, Human TMP21 Protein, mFc Tag, TMP21

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	跨膜 p24 运输蛋白 10, Human TMP21 Protein, mFc Tag, TMP21
Catalog Number	KMP3068
Product Description	The Human TMP21 Protein(KMP3068) is produced in HEK293 Cells. The target gene encoding the human TMED10 (NP_006818.3) (Met1-Arg185) is expressed with the Fc region of mouse IgG1 at the C-terminus.
Molecular Name	TMP21
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>85% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	TMED10 disrupts the complex formation between TGF-beta type I (also termed ALK5) and type II receptors (TbetaRII). Misexpression studies revealed that TMED10 attenuated TGF-beta-mediated signaling. A 20-amino acid-long region from Thr(91) to Glu(110) within the extracellular region of TMED10 was found to be crucial for TMED10 interaction with both ALK5 and TbetaRII. Synthetic peptides corresponding to this region inhibit both TGF-beta-induced Smad2 phosphorylation and Smad-dependent transcriptional reporter activity. In a xenograft cancer model, where previously TGF-beta was shown to elicit tumor-promoting effects, gain-of-function and loss-of-function studies for TMED10 revealed a decrease and increase in the tumor size, respectively. That TMED10 expression levels are the key determinant for efficiency of TGF-beta receptor complex formation and signaling.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	44 kDa

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