Human NPC2 Protein, His Tag_天津卡梅德科技发展有限公司

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Human NPC2 Protein, His Tag

Human NPC2 Protein, His Tag

产品编号

KMP3058

别名

细胞内胆固醇转运蛋白 2, Human NPC2 Protein, His Tag, NPC2

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	细胞内胆固醇转运蛋白 2, Human NPC2 Protein, His Tag, NPC2
Catalog Number	KMP3058
Product Description	The Human NPC2 Protein(KMP3058) is produced in HEK293 Cells. The target gene encoding the human NPC2 (NP_006423.1) (Met1-Leu151) is expressed with a polyhistidine tag at the C-terminus.
Molecular Name	NPC2
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Niemann-Pick Type C2 (NPC2) plays an important role in the regulation of intracellular cholesterol homeostasis via direct binding with free cholesterol. NPC2 is an intralysosomal protein that binds cholesterol in vitro. NPC2 is a small lysosomal glycoprotein that binds cholesterol with submicromolar affinity. Deficiency in NPC2 is the cause of Niemann-Pick type C2 disease, a fatal neurovisceral disorder characterized by the accumulation of cholesterol in lysosomes. Niemann-Pick disease, type C2 (NPC2) protein is one of the most abundant components of the epididymal fluid and contains a functional cholesterol-binding site that can transfer cholesterol between membranes, it has been suggested for years that NPC2 could be involved in the regulation of cholesterol levels in spermatozoa during epididymal maturation.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	16 kDa

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