Human LAIR1 Protein, His Tag_天津卡梅德科技发展有限公司

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Human LAIR1 Protein, His Tag

Human LAIR1 Protein, His Tag

产品编号

KMP3052

别名

白细胞相关免疫球蛋白样受体-1, Human LAIR1 Protein, His Tag, LAIR1

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	白细胞相关免疫球蛋白样受体-1, Human LAIR1 Protein, His Tag, LAIR1
Catalog Number	KMP3052
Product Description	The Human LAIR1 Protein(KMP3052) is produced in HEK293 Cells. The target gene encoding the human LAIR1 (AAF71275.2) (Met1-Tyr165) is expressed with a polyhistidine tag at the C-terminus. The purified protein is biotinylated in vitro.
Molecular Name	LAIR1
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Leukocyte-associated Ig-like receptor-1 (LAIR1) is a surface molecule expressed on human mononuclear leukocytes that functions as an inhibitory receptor on human NK cells. In addition to NK cells, LAIR1 is expressed on T cells, B cells, macrophages, and dendritic cells. It is predicted to mediate inhibitory functions based on the presence of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in its cytoplasmic domain. Cross-linking of LAIR1 on human T cell clones results in inhibition of cytotoxicity only in T cell clones that lack CD28 and can spontaneously lyse certain targets in vitro. Moreover, the cytolytic activity of freshly isolated T cells, which is thought to be mainly due to "effector" T cells, can be inhibited by anti-LAIR1 mAb. Thus, LAIR1 functions as an inhibitory receptor not only on NK cells but also on human T cells. This indicates that LAIR1 provides a mechanism of regulation of effector T cells and may play a role in the inhibition of unwanted bystander responses mediated by Ag-specific T cells.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	17.2 kDa

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