Human CD247 Protein_天津卡梅德科技发展有限公司

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Human CD247 Protein

Human CD247 Protein

产品编号

KMP3046

别名

T细胞表面糖蛋白CD3 Zeta链, Human CD247 Protein, CD247

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	T细胞表面糖蛋白CD3 Zeta链, Human CD247 Protein, CD247
Catalog Number	KMP3046
Product Description	The Human CD247 Protein(KMP3046) is produced in E. coli. The target gene encoding the human CD247 (P20963-1) (Arg52-Arg164) is expressed.
Molecular Name	CD247
Species	Human
Host	E. coli
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	50mM Tris, 150mM NaCl, pH7.5
Background	CD247, also known as CD3-ZETA, belongs to the CD3Z/FCER1G family. It contains 3 ITAM domains. As a -cell receptor zeta, CD247 forms the T-cell receptor-CD3 complex together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and –epsilon. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for CD247 gene. Defects in CD247 can cause immunodeficiency due to defect in CD3-zeta. An immunological deficiency characterized by T-cells impaired immune response to alloantigens, tetanus toxoid and mitogens. CD247 may play a role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	13.18 kDa

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