Human RSPO2 Protein, hFc Tag_天津卡梅德科技发展有限公司

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Human RSPO2 Protein, hFc Tag

Human RSPO2 Protein, hFc Tag

产品编号

KMP3032

别名

R-Spondin 2同系物, Human RSPO2 Protein, hFc Tag, RSPO2

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	R-Spondin 2同系物, Human RSPO2 Protein, hFc Tag, RSPO2
Catalog Number	KMP3032
Product Description	The Human RSPO2 Protein(KMP3032) is produced in HEK293 Cells. The target gene encoding the Human RSPO2 (Q6UXX9-1, with mutations L186P) (Met1-Gly205) is expressed with the Fc region of human IgG1 at the C-terminus.
Molecular Name	RSPO2
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	Histidine, Arginine, 120mM NaCl, 0.02% Tween80, 5% Sucrose, pH6.0
Background	R-spondin-2, also known as RSPO2, synergizes with Wnt to activate beta-catenin. RSPO2 is secreted proteins that regulate beta-catenin signaling. Activator of the beta-catenin signaling cascade leads to TCF-dependent gene activation. Action both in the canonical Wnt / beta- catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled / LRP receptors. Probably also acts as a ligand for frizzled and LRP receptors. The encoding gene Rspo2 was identified as a novel common integration site for the mouse mammary tumor virus in viral induced mouse mammary tumors. Rspo2 and Rspo2 / Wnt1 tumors contained many spindle cells, consistent with an epithelial-mesenchymal transformation phenotype. When Rspo2 and Rspo2 / Wnt1 tumor cells were transferred into naive mice, they exhibited greater metastatic activity than cells derived from Wnt1 tumors.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	48.01 kDa

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