Human ATP1B4 Protein, His Tag_天津卡梅德科技发展有限公司

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Human ATP1B4 Protein, His Tag

Human ATP1B4 Protein, His Tag

产品编号

KMP3024

别名

ATPase Na+/K+ 转运家族成员 beta 4, Human ATP1B4 Protein, His Tag, ATP1B4

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	ATPase Na+/K+ 转运家族成员 beta 4, Human ATP1B4 Protein, His Tag, ATP1B4
Catalog Number	KMP3024
Product Description	The Human ATP1B4 Protein(KMP3024) is produced in E. coli. The target gene encoding the human ATP1B4 (Q9UN42-1) (Tyr132-Thr357) is expressed with a polyhistidine tag at the N-terminus.
Molecular Name	ATP1B4
Species	Human
Host	E. coli
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	20mM Tris, pH8.0
Background	ATP1B4 is a member of the X(+)/potassium ATPases subunit beta family. It is highly expressed in skeletal muscle and at a lower level in heart. ATP1B4 gene can be found in all vertebrate genomes sequenced to date. However, this gene has undergone a change in function in placental mammals compared to other species. Specifically, in fish, Avian, and amphibian species, this gene encodes plasma membrane-bound beta-subunits of Na, K-ATPase. In placental mammals, the encoded protein interacts with the nuclear transcriptional coregulator SKIP and may be involved in the regulation of TGF-beta signaling. ATP1B4 may act as a transcriptional coregulator during muscle development through its interaction with SNW1. Na+, K+-ATPase is an important regulator of intracellular electrolyte levels in most mammalian cells. It is a Mg2+-dependent transport pump responsible for maintaining the low intracellular Na+:K+ ratio that is essential for cell homeostasis and physiological function. It catalyzes the active uptake of K+ and extrusion of Na+ at the expense of hydrolyzing ATP with a stoichiometry of 3 Na+ for 2 K+. ATP1B4 has lost its ancestral function as a Na,K-ATPase beta-subunit.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	27.35 kDa

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