Human IGFBP-6 Protein, His Tag_天津卡梅德科技发展有限公司

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Human IGFBP-6 Protein, His Tag

Human IGFBP-6 Protein, His Tag

产品编号

KMP3023

别名

胰岛素样生长因子结合蛋白 6, Human IGFBP-6 Protein, His Tag, IGFBP-6

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	胰岛素样生长因子结合蛋白 6, Human IGFBP-6 Protein, His Tag, IGFBP-6
Catalog Number	KMP3023
Product Description	The Human IGFBP-6 Protein(KMP3023) is produced in HEK293 Cells. The target gene encoding the human IGFBP6 (P24592) (Met 1-Gly 240) is fused with a polyhistidine tag at the C-terminus.
Molecular Name	IGFBP-6
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Insulin-like growth factor-binding protein 6 (IGFBP6) is a 24-kDa protein that binds insulin-like growth factor 1 (IGF-1) and IGF-2 with high affinity and inhibits IGF action in vitro. The Insulin-like growth factor-binding protein also known as IGFBP serves as a carrier protein for Insulin-like growth factor 1. IGFBPs are distinct but are sharing regions with strong homology. All members of the IGFBP family bind IGF-I and IGF-II with about equal affinity. Insulin-like growth factor (IGF) binding proteins (IGFBPs) have been shown to either inhibit or enhance the action of IGF or act in an IGF-independent manner in the prostate. IGF-binding protein-4 (IGFBP-4) inhibits IGF-I action in vitro and is the most abundant IGFBP in the rodent arterial wall. IGFBP6 is directly downregulated by the beta-catenin/TCF complex in desmoid tumors, and imply a role for the IGF axis in the proliferation of desmoid tumors. There is mounting evidence that the structure of the IGFBP proteins plays a key role in the regulation of IGF bioavailability, by modulating its molecular size, capillary membrane permeability, target tissue specificity, cell membrane adherence, and IGF affinity.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	23.9 kDa

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