Human MICA Protein, hFc Tag_天津卡梅德科技发展有限公司

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Human MICA Protein, hFc Tag

Human MICA Protein, hFc Tag

产品编号

KMP3008

别名

MHCⅠ类分子相关蛋白A, Human MICA Protein, hFc Tag, MICA

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	MHCⅠ类分子相关蛋白A, Human MICA Protein, hFc Tag, MICA
Catalog Number	KMP3008
Product Description	The Human MICA Protein(KMP3008) is produced in HEK293 Cells. The target gene encoding the human MICA (AAH16929.1) (Met1-Gln308) is expressed with the Fc region of human IgG1 at the C-terminus.
Molecular Name	MICA
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	MHC class I chain-related molecules A (MICA) is one of the genes in the HLA class I region, which belongs to the MHC class I family. It is the member of the non-classical class I family that displays the greatest degree of polymorphism. The MICA protein product is expressed on the cell surface, although unlike canonical class I molecules do not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by NK cells, NKT cells, and most of the subtypes of T cells. The Natural killer group 2D (NKG2D), a C-type lectin-like activating immunoreceptor, is a receptor of MICA, which was detected on most gamma-delta T cells, CD8+ alpha-beta T cells, and natural killer (NK) cells. Effector cells from all these subsets could be stimulated by the ligation of NKG2D. Engagement of NKG2D activated cytolytic responses of gamma-delta T cells and NK cells against transfectants and epithelial tumor cells expressing MICA. The MICA system is a novel, Avidin-free immunohistochemical detection system that provides a significant increase in sensitivity compared to traditional immunodetection systems.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	59.86 kDa

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