Human IL24 Protein, mFc Tag_天津卡梅德科技发展有限公司

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Human IL24 Protein, mFc Tag

Human IL24 Protein, mFc Tag

产品编号

KMP3002

别名

白细胞介素 24, Human IL24 Protein, mFc Tag, IL24

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	白细胞介素 24, Human IL24 Protein, mFc Tag, IL24
Catalog Number	KMP3002
Product Description	The Human IL24 Protein(KMP3002) is produced in HEK293 Cells. The target gene encoding the human IL24 (NP_001172085.1) (Met1-Leu207) is expressed with the Fc region of mouse IgG1 at the C-terminus.
Molecular Name	IL24
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>80% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Interleukin-24 (IL-24) also known as Melanoma differentiation-associated gene 7 protein (MDA-7) is a member of the IL10 family of cytokines. IL-24/MDA-7/IL24 can induce apoptosis selectively in various cancer cells. Overexpression of IL-24 leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Human IL-24/MDA-7/IL24 is secreted by activated peripheral blood mononuclear cells and is the ligand for two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2. Northern blot analysis revealed IL-24/MDA-7/IL24 expression in human tissues associated with the immune system such as the spleen, thymus, peripheral blood leukocytes, and normal melanocytes. IL-24/MDA-7/IL24 binding to either its endogenous receptors on human keratinocytes or to ectopically expressed receptors on baby hamster kidney cells leads to activation of the signal transducers and activators of transcription.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	44.6 kDa

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