Human SIGIRR Protein, His Tag_天津卡梅德科技发展有限公司

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Human SIGIRR Protein, His Tag

Human SIGIRR Protein, His Tag

产品编号

KMP2983

别名

白细胞介素1受体相关蛋白, Human SIGIRR Protein, His Tag, SIGIRR

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	白细胞介素1受体相关蛋白, Human SIGIRR Protein, His Tag, SIGIRR
Catalog Number	KMP2983
Product Description	The Human SIGIRR Protein(KMP2983) is produced in HEK293 Cells. The target gene encoding the Human SIGIRR (Q6IA17-1) (Met1-His118) is expressed, fused with a polyhistidine tag at the C-terminus. The purified protein is biotinylated in vitro.
Molecular Name	SIGIRR
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Single Ig IL-1-related receptor (SIGIRR) or TIR8 is a member of Toll-like receptor-interleukin 1 receptor signaling (TLR-IL-1R) receptor superfamily. Although SIGIRR/TIR8 shows the typical conserved motifs that characterize the IL-1R and Toll superfamily, it is structurally and functionally distinct from both. SIGIRR/TIR8 has only one Ig domain in its extracellular portion whereas the IL-1R family contains three Ig folds. An unusually long cytoplasmic domain is reminiscent of the structure of drosophila Toll, yet the SIGIRR peptide sequence is more closely related to IL-1RI. SIGIRR/TIR8 was mainly expressed in mouse and human epithelial tissues such as kidney, lung and gut. Resting and activated T and B lymphocytes and monocytes-macrophages expressed little or no SIGIRR/TIR8, with the exception of the mouse GG2EE macrophage line. Inflammation is enhanced in SIGIRR-deficient mice. SIGIRR negatively modulates immune responses. Inflammation is enhanced in SIGIRR-deficient mice, as shown by their enhanced chemokine induction after IL-1 injection and reduced threshold for lethal endotoxin challenge.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	13.98 kDa

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