Human VSIG4 Protein, hFc Tag_天津卡梅德科技发展有限公司

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Human VSIG4 Protein, hFc Tag

Human VSIG4 Protein, hFc Tag

产品编号

KMP2982

别名

含 V 组和免疫球蛋白结构域 4, Human VSIG4 Protein, hFc Tag, VSIG4

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	含 V 组和免疫球蛋白结构域 4, Human VSIG4 Protein, hFc Tag, VSIG4
Catalog Number	KMP2982
Product Description	The Human VSIG4 Protein(KMP2982) is produced in HEK293 Cells. The target gene encoding the human VSIG4 (NP_009199.1) (Met1-Pro283) is expressed with the Fc region of human IgG1 at the C-terminus. The purified protein is biotinylated in vitro.
Molecular Name	VSIG4
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	VSIG4 (V-set and immunoglobulin domain containing 4), also known as complement receptor of the immunoglobulin superfamily (CRIg) and Z39Ig, is a type I transmembrane glycoprotein. It is a B7 family-related protein and an Ig superfamily member. In contrast to the B7 family members which contain two IgG domains, VSIG4 contains one complete V-type I g domain and a truncated C-type I g domain. VSIG4 is exclusively expressed on tissue resident macrophages and binds to multimers of C3b and iC3b that are covalently attached to particle surfaces. No VSIG4 expression appears to be present in T and B cells. VSIG4 functions as a negative regulator of T cell activation, and may be involved in the maintenance of peripheral T cell tolerance, and is also identified as a potent suppressor of established inflammation. Mouse VSIG4 is synthesized as a 28 amino acid precursor that contains a signal sequence, a V-type I g domain (aa 36-115), one potential N-linked glycosylation site, and a single transmembrane domain. The V-type I g domain of mouse VSIG4 shares 86% and 8% aa sequence identity with the V-type I g domains of rat and human VSIG4, respectively.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	56.2 kDa

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