Human TIMD4 Protein, His Tag_天津卡梅德科技发展有限公司

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Human TIMD4 Protein, His Tag

Human TIMD4 Protein, His Tag

产品编号

KMP2981

别名

T细胞免疫球蛋白和粘蛋白结构域蛋白4, Human TIMD4 Protein, His Tag, TIMD4

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	T细胞免疫球蛋白和粘蛋白结构域蛋白4, Human TIMD4 Protein, His Tag, TIMD4
Catalog Number	KMP2981
Product Description	The Human TIMD4 Protein(KMP2981) is produced in HEK293 Cells. The target gene encoding the human TIMD4 (AAH08988.1) extracellular domain (Met 1-Leu 315) is expressed, fused with a polyhistidine tag at the C-terminus. The purified protein is biotinylated in vitro.
Molecular Name	TIMD4
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	A type I transmembrane protein called TIM4 (T-cell immunoglobulin- and mucin-domain-containing molecule; also known as TIMD4), which belongs to the immunoglobulin superfamily and TIM family. TIM4 is involved in regulating T-cell proliferation and lymphotoxin signaling. It is a ligand for HAVCR1/TIMD1. Recent reports indicate that dendritic cell (DC)-derived T-cell immunoglobulin and mucin domain molecule (TIM)-4, which is expressed on dendritic cells and macrophages, plays an important role in the initiation of T(H)2 polarization. TIM4 bound apoptotic cells by recognizing phosphatidylserine via its immunoglobulin domain. The expression of TIM4 in fibroblasts enhanced their ability to engulf apoptotic cells. TIM4 is phosphatidylserine receptor for the engulfment of apoptotic cells, and may also be involved in intercellular signalling in which exosomes are involved. Modulation of TIM4 production in dendritic cells (DCs) represents a novel therapeutic approach for the treatment of peanut allergy. The interaction of TIM1/TIM4 played a critical role in sustaining the polarization status of Th2 cells in allergic rhinitis (AR) patients. Cross-linking FcgammaRI by antigen/IgG complexes increased the production of TIM4 by dendritic cells via upregulating tumor necrosis factor-alpha in DCs. Specific immunotherapy (SIT) suppresses the skewed Th2 responses via disrupting the interaction of TIM1/TIM4 in antigen-specific Th2 cells.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	32.7 kDa

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