Human DR3 Protein, hFc Tag_天津卡梅德科技发展有限公司

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Human DR3 Protein, hFc Tag

Human DR3 Protein, hFc Tag

产品编号

KMP2977

别名

死亡受体3, Human DR3 Protein, hFc Tag, DR3

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	死亡受体3, Human DR3 Protein, hFc Tag, DR3
Catalog Number	KMP2977
Product Description	The Human DR3 Protein(KMP2977) is produced in HEK293 Cells. The target gene encoding the human TNFRSF25 (NP_683867.1) (Met1-Gln199) is expressed with the Fc region of human IgG1 at the C-terminus. The purified protein is biotinylated in vitro.
Molecular Name	DR3
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Tumor necrosis factor receptor superfamily, member 25 (TNFRSF25), also known as Death receptor 3 (DR3) or TNFRSF12 is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. TNFRSF25/DR3/TNFRSF12 has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this TNFRSF25 encoding gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	45.9 kDa

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