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Human IL17 Protein, His Tag

Human IL17 Protein, His Tag

产品编号

KMP2970

别名

白细胞介素 17, Human IL17 Protein, His Tag, IL17

规格
  • 50ug
  • 100ug
  • 200ug
产品介绍
Alias白细胞介素 17, Human IL17 Protein, His Tag, IL17
Catalog NumberKMP2970
Product DescriptionThe Human IL17 Protein(KMP2970) is produced in Insect Cells. The target gene encoding the mature form of human IL17A (Q16552, with mutation Thr 26 Ala) (Gly24-Ala155) is expressed with a polyhistidine tag at the N-terminus.
Molecular NameIL17
SpeciesHuman
HostInsect Cells
Size50ug, 100ug, 200ug
Purity>95% as determined by SDS-PAGE
PurificationAffinity purification
Endotoxin<1.0 EU/ug determined by the LAL method
Formulation20mM PB, 500mM NaCl, 10% Glycerol, pH7.0
BackgroundIL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. The IL-17 family of cytokines includes six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by multiple cell types. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis, and multiple sclerosis.
Storage ConditionAliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping ConditionIn general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight17.2 kDa

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