Human NR3C1 Protein, His Tag_天津卡梅德科技发展有限公司

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Human NR3C1 Protein, His Tag

Human NR3C1 Protein, His Tag

产品编号

KMP2969

别名

糖皮质激素受体, Human NR3C1 Protein, His Tag, NR3C1

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	糖皮质激素受体, Human NR3C1 Protein, His Tag, NR3C1
Catalog Number	KMP2969
Product Description	The Human NR3C1 Protein(KMP2969) is produced in E. coli. The target gene encoding the Human NR3C1 (P04150) (Pro417-Gly506) is expressed with a polyhistidine tag at the C-terminus.
Molecular Name	NR3C1
Species	Human
Host	E. coli
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	NR3C1 (Nuclear Receptor Subfamily 3 Group C Member 1) is a Protein Coding gene. This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. NR3C1 is a transcriptional regulator of many drug-metabolizing enzymes and anti-inflammatory molecules. NR3C1 polymorphisms associate with obesity, muscle strength, and cortisol sensitivity. Glucocorticoid receptor gene polymorphism (NR3C1 646 C>G) may play an important role in the development of severe bronchial asthma and resistance to glucocorticoids (GCs). Disturbances in the structure and function of the glucocorticoid receptor (GR) alter the glucocorticoid regulation of the corticotropin-releasing hormone, which leads to nonspecific activation of numerous receptors in the brain and alters the metabolism.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	10.95 kDa

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