Human CLEC12A Protein, Avi Tag, Fc Tag_天津卡梅德科技发展有限公司

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Human CLEC12A Protein, Avi Tag, Fc Tag

Human CLEC12A Protein, Avi Tag, Fc Tag

产品编号

KMP2951

别名

C型凝集素结构域家族12成员A, Human CLEC12A Protein, Avi Tag, Fc Tag, CLEC12A

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	C型凝集素结构域家族12成员A, Human CLEC12A Protein, Avi Tag, Fc Tag, CLEC12A
Catalog Number	KMP2951
Product Description	The Human CLEC12A Protein(KMP2951) is produced in HEK293 Cells. The target gene encoding the human CLEC12A (EAW96132.1) (His75-Ala275) is expressed with a N-terminal Avi tag followed by a Fc region of human IgG1 tag. The expressed protein is biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed..
Molecular Name	CLEC12A
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	CLEC12A is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. CLEC12A is a negative regulator of granulocyte and monocyte function. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. C-type lectins are the most diverse and prevalent lectin family in immunity. Using a novel CLEC12A -specific monoclonal antibody, experiments had shown that human CLEC12A was expressed primarily on myeloid cells, including granulocytes, monocytes, macrophages, and dendritic cells. Although CLEC12A was highly N-glycosylated in primary cells, the level of glycosylation was found to vary between cell types. CLEC12A surface expression was down-regulated during inflammatory/activation conditions in vitro, as well as during an in vivo model of acute inflammation. This suggests that CLEC12A may be involved in the control of myeloid cell activation during inflammation.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	51.61 kDa

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