Human SIRPG Protein, hFc Tag_天津卡梅德科技发展有限公司

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Human SIRPG Protein, hFc Tag

Human SIRPG Protein, hFc Tag

产品编号

KMP2932

别名

信号调节蛋白γ, Human SIRPG Protein, hFc Tag, SIRPG

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	信号调节蛋白γ, Human SIRPG Protein, hFc Tag, SIRPG
Catalog Number	KMP2932
Product Description	The Human SIRPG Protein(KMP2932) is produced in HEK293 Cells. The target gene encoding the human SIRPG ( NP_061026.2) (Met1-Ser364) is expressed with the Fc region of human IgG1 at the C-terminus.
Molecular Name	SIRPG
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, 2mM EDTA, pH7.4
Background	Signal-regulatory protein gamma (SIRPG/SIRP gamma) also known as CD172 antigen-like family member B, CD172g, and CD172g antigen, is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. SIRPG/SIRP gamma/CD172g is a probable immunoglobulin-like cell surface receptor. On binding with CD47, SIRPG can mediate cell-cell adhesion. SIRPG/SIRP gamma is engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation. SIRPG/SIRP gamma/CD172g is detected in liver, and at very low levels in brain, heart, lung, pancreas, kidney, placenta and skeletal muscle. Expressed on CD4+ T-cells, CD8+ T-cells, CD56-bright natural killer (NK) cells, CD20+ cells, and all activated NK cells. This cytokine is mainly present in the paracortical T-cell area of lymph nodes, with only sparse positive cells in the mantle and in the germinal center of B-cell follicles. In the thymus, SIRPG is primarily expressed in the medulla on mature T-lymphocytes that have undergone thymic selection.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	64.1 kDa

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