Human USP7 Protein, His Tag, GST Tag_天津卡梅德科技发展有限公司

>>

>>

>>

>

Human USP7 Protein, His Tag, GST Tag

Human USP7 Protein, His Tag, GST Tag

产品编号

KMP2915

别名

泛素特异性肽酶 7, Human USP7 Protein, His Tag, GST Tag, USP7

规格

50ug
100ug
200ug

DATASHEET MSDS

立即询价加入询价列表大包装定制

产品介绍

Alias	泛素特异性肽酶 7, Human USP7 Protein, His Tag, GST Tag, USP7
Catalog Number	KMP2915
Product Description	The Human USP7 Protein(KMP2915) is produced in Insect Cells. The target gene encoding full length of human USP7 (NP_003461.2) (Met 1-Asn 1102) is fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
Molecular Name	USP7
Species	Human
Host	Insect Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	50mM Tris, 100mM NaCl, pH8.0
Background	Ubiquitin carboxyl-terminal hydrolase 7, also known as Ubiquitin thioesterase 7, Herpesvirus-associated ubiquitin-specific protease, Ubiquitin-specific-processing protease 7, USP7 and HAUSP, is a widely expressed protein that belongs to the peptidase C19 family. USP7 is a member of the family of deubiquitinating enzymes. It is involved in the regulation of stress response pathways, epigenetic silencing and the progress of infections by DNA viruses. USP7 is a protein with a cysteine peptidase core, N- and C-terminal domains required for protein-protein interactions. USP7 contributes to epigenetic silencing of homeotic genes by Polycomb (Pc). USP7 cleaves ubiquitin fusion protein substrates. It deubiquitinates TP53/p53 and MDM2 and strongly stabilizes TP53 even in the presence of excess MDM2. USP7 also induces TP53-dependent cell growth repression and apoptosis. USP7 has key roles in the p53 pathway whereby it stabilizes both p53 and MDM2. Herpes simplex virus type 1 (HSV-1) regulatory protein ICP stimulates lytic infection and the reactivation of quiescent viral genomes. ICP interacts very strongly with USP7. USP7-mediated stabilization of ICP is dominant over ICP-induced degradation of USP7 during productive HSV-1 infection. The biological significance of the ICP-USP7 interaction may be most pronounced in natural infection situations, in which limited amounts of ICP are expressed.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	156 kDa

推荐产品

400-621-6806
614353794
周一至周五 9:00-18:00
0