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Human HSP70 Protein, His Tag

Human HSP70 Protein, His Tag

产品编号

KMP2913

别名

热休克蛋白家族A成员4, Human HSP70 Protein, His Tag, HSP70

规格
  • 50ug
  • 100ug
  • 200ug
产品介绍
Alias热休克蛋白家族A成员4, Human HSP70 Protein, His Tag, HSP70
Catalog NumberKMP2913
Product DescriptionThe Human HSP70 Protein(KMP2913) is produced in HEK293 Cells. The target gene encoding the human HSPA1A (NP_005336.3) (Ala2-Asp641) is expressed with a polyhistidine tag at the N-terminus.
Molecular NameHSP70
SpeciesHuman
HostHEK293 Cells
Size50ug, 100ug, 200ug
Purity>95% as determined by SDS-PAGE
PurificationAffinity purification
Endotoxin<1.0 EU/ug determined by the LAL method
FormulationPBS, pH7.4
BackgroundHSPA1A is a member of the Hsp70 protein family. The 70 kilodalton heat shock proteins (Hsp70s) are a family of ubiquitously expressed heat shock proteins. HSP are abundant and conserved proteins present in all cells. Upon temperature shock or other stress stimuli, HSP is synthesized intracellularly, which may protect cells from protein denaturation or death. Extracellularly, HSP can serve a cytokine function to initiate both innate and adaptive immunity through activation of APC. HSP serves also a chaperone function and facilitates the presentation of antigen peptide to T cells. Molecular chaperones of the Hsp70 family have diverse functions in cells. They assist the folding of newly synthesized and stress-denatured proteins, as well as the import of proteins into organelles, and the dissociation of aggregated proteins. The well-conserved Hsp70 chaperones are ATP dependent: binding and hydrolysis of ATP regulate their interactions with unfolded polypeptide substrates, and ATPase cycling is necessary for their function. All cellular functions of Hsp70 chaperones use the same mechanism of ATP-driven polypeptide binding and release.
Storage ConditionAliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping ConditionIn general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight71.4 kDa

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