Human CTHRC1 Protein, hFc Tag_天津卡梅德科技发展有限公司

>>

>>

>>

>

Human CTHRC1 Protein, hFc Tag

Human CTHRC1 Protein, hFc Tag

产品编号

KMP2910

别名

含胶原三螺旋重复蛋白1, Human CTHRC1 Protein, hFc Tag, CTHRC1

规格

50ug
100ug
200ug

DATASHEET MSDS

立即询价加入询价列表大包装定制

产品介绍

Alias	含胶原三螺旋重复蛋白1, Human CTHRC1 Protein, hFc Tag, CTHRC1
Catalog Number	KMP2910
Product Description	The Human CTHRC1 Protein(KMP2910) is produced in HEK293 Cells. The target gene encoding the Human CTHRC1 (NP_612464.1) (Met1-Lys243) is expressed with the Fc region of human IgG1 at the C-terminus.
Molecular Name	CTHRC1
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Collagen triple helix repeat-containing protein 1, also known as Protein NMTC1, and CTHRC1, is a secreted protein that is glycosylated and highly conserved from lower chordates to mammals. CTHRC1 expression was not detectable in normal arteries. However, it is transiently expressed in the arterial wall in response to injury where it may contribute to vascular remodeling by limiting collagen matrix deposition and promoting cell migration. A short collagen motif with 12 Gly-X-Y repeats appears to be responsible for trimerization of the CTHRC1 protein and this renders the molecule susceptible to cleavage by collagenase. CTHRC1 overexpression caused a dramatic reduction in collagen type I mRNA and protein levels. Currently available data indicate that Cthrc1 expression in vascular cells regulates transforming growth factor beta responsiveness, thereby impacting transforming growth factor beta target genes, including collagens. Additionally, CTHRC1 increases bone mass as a positive regulator of osteoblastic bone formation and offers an anabolic approach for the treatment of osteoporosis.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	49.8 kDa

推荐产品

400-621-6806
614353794
周一至周五 9:00-18:00
0