Rhesus B7-H4 Protein, His Tag

产品编号

KMP4362

别名

含 V 组结构域的 T 细胞激活抑制剂1, B7-H4 Protein, Rhesus B7-H4 Protein, His Tag

规格

50ug
100ug
200ug

DATASHEET COA

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产品介绍

Alias	含 V 组结构域的 T 细胞激活抑制剂1, B7-H4 Protein, Rhesus B7-H4 Protein, His Tag
Catalog Number	KMP4362
Product Description	The Rhesus B7-H4 Protein(KMP4362) is produced in HEK293 Cells. A DNA sequence encoding the Cynomolgus/Rhesus VTCN1 (A0A2K5U6P5-1/F7B770-1) (Phe29-Ala258) is expressed with a polyhistidine tag at the C-terminus.
Molecular Name	B7-H4
Species	Rhesus
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Concentration	联系销售经理获得最新批次的浓度
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	V-set domain-containing T-cell activation inhibitor 1, also known as B7X, B7H4, B7S1, and VTCN1, is a single-pass type-III membrane protein belonging to the B7 family of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands on T lymphocytes. They provide costimulatory signals that regulate T cell responses. A soluble form of B7H4 has also been detected. B7X/VTCN1/B7H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, B7X/VTCN1/B7H4 plays an important role, together with regulatory T-cells(Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. B7X/VTCN1/B7H4 is also involved in promoting epithelial cell transformation. This membrane protein can be up-regulated by IL6/interleukin-6 and IL10/interleukin-10 and inhibited by CSF2/GM-CSF and IL4/interleukin-4 on antigen-presenting cells.
Cross-reactivity	No cross-reactivity with other antigens or proteins.
Predicted N Terminus	Phe 29
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	26.8 kDa
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。
Temperature Range	Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -25℃. Avoid repeated freeze-thaw cycles.