Rat ICOS ligand Protein, His Tag

产品编号

KMP4266

别名

诱导型T细胞共刺激物配体, ICOS ligand Protein, Rat ICOS ligand Protein, His Tag

规格

50ug
100ug
200ug

DATASHEET COA

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产品介绍

Alias	诱导型T细胞共刺激物配体, ICOS ligand Protein, Rat ICOS ligand Protein, His Tag
Catalog Number	KMP4266
Product Description	The Rat ICOS ligand Protein(KMP4266) is produced in HEK293 Cells. A DNA sequence encoding the rat ICOSLG (XP_006223893.1) (Met1-Lys261) is expressed with a polyhistidine tag at the C-terminus.
Molecular Name	ICOS ligand
Species	Rat
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Concentration	联系销售经理获得最新批次的浓度
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. The present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production, and germinal center formation.
Cross-reactivity	No cross-reactivity with other antigens or proteins.
Predicted N Terminus	Met
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	28.6 kDa
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。
Temperature Range	Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -25℃. Avoid repeated freeze-thaw cycles.