Human BTN3A1 Protein

产品编号

KMP3300

别名

嗜乳脂蛋白亚家族 3 成员 A1, Human BTN3A1 Protein, BTN3A1

规格

50ug
100ug
200ug

DATASHEET COA

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产品介绍

Alias	嗜乳脂蛋白亚家族 3 成员 A1, Human BTN3A1 Protein, BTN3A1
Catalog Number	KMP3300
Product Description	The Human BTN3A1 Protein(KMP3300) is produced in HEK293 Cells. The target gene encoding the human BTN3A1 (NP_919423.1) (Met1-Gly254) is expressed with five amino acids (DDDDK) at the C-terminus.
Molecular Name	BTN3A1
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Concentration	联系销售经理获得最新批次的浓度
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	BTN3A1 has the structure of a type I receptor of the Ig superfamily and is part of a family of seven BTN receptors encoded by genes in the MHC. BTN molecules are composed of two Ig domains (IgV, IgC2), a single transmembrane domain, and a large carboxyl-terminal domain termed B3.2 (or PRYSPRY) located in the cell cytoplasm. There are three human BTN3A loci, BTN3A1, BTN3A2, and BTN3A3, and clear orthologs of BTN3A molecules, now called CD277, are absent from the mouse genome. Despite its similarity to B7 molecules, BTN3A1 was proposed to act not as a coreceptor or costimulatory molecule, but rather to directly present pAg to the γδ TCR in a manner analogous to MHC-restricted peptide presentation. However, this model of BTN3A1 function has been challenged by conflicting data, which show pAg binding to a positively charged pocket in the cytosolic B3.2 domain, and that BTN3A1 does not directly engage the γδ TCR. This contradictory picture has emerged as a result of the complexity of the system and in particular by the use of endogenous and exogenous routes of Ag delivery in in vitro assays.
Cross-reactivity	No cross-reactivity with other antigens or proteins.
Predicted N Terminus	Met
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	24.8 kDa
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。
Temperature Range	Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -25℃. Avoid repeated freeze-thaw cycles.